反応 #53894

ord-526555117a2b4031930b54adf72a3654

反応方程式

CN
methylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl chloroformate
→
CNCCCCC[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(C(F)(F)F)cc2)CC1
trans-Methyl-[4-(5-methylamino-pentyl)-cyclohexyl]-carbamic acid 4-trifluoromethyl-phenyl ester

反応物

CN
methylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl chloroformate

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-trifluoromethyl-phenyl chloroformate were reacted, followed by treatment with methylamine to give trans-Methyl-[4-(5-methylamino-pentyl)-cyclohexyl]-carbamic acid 4-trifluoromethyl-phenyl ester, MS: 401 (MH+).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06858651B2uspto-grants-2005_02