反応 #53893

ord-83a8a8876b784a2cbfd596a15602f857

反応方程式

C=CCN
allylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl chloroformate
→
C=CCNCCCCC[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(C(F)(F)F)cc2)CC1
trans-{4-[5-(Allylamino)-pentyl]-cyclohexyl}-methyl-carbamic acid 4-trifluoromethyl-phenyl ester

反応物

C=CCN
allylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl chloroformate

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-trifluoromethyl-phenyl chloroformate were reacted, followed by treatment allylamine to give trans-{4-[5-(Allylamino)-pentyl]-cyclohexyl}-methyl-carbamic acid 4-trifluoromethyl-phenyl ester, MS: 427 (MH+).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06858651B2uspto-grants-2005_02