反応 #53879

ord-27efb7bec3cd4780bf83f5e4a963c53c

反応方程式

CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt
O=C(Cl)Oc1ccc(F)c(F)c1
3,4-difluoro-phenyl chloroformate
C=CCCN
N-allylmethylamine
→
C=CCN(C)CCCCC[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(F)c(F)c2)CC1
trans-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-methyl-carbamic acid 3,4-difluoro-phenyl ester

反応物

CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt
O=C(Cl)Oc1ccc(F)c(F)c1
3,4-difluoro-phenyl chloroformate
C=CCCN
N-allylmethylamine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt and 3,4-difluoro-phenyl chloroformate were reacted, followed by treatment with N-allylmethylamine to yield trans-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-methyl-carbamic acid 3,4-difluoro-phenyl ester, MS: 409 (MH+).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06858651B2uspto-grants-2005_02