反応 #538555

反応方程式

3-(4-fluoro-phenyl)-pyridin-2-ylamine

ethoxycarbonyl isothiocyanate

→

title compound

N-(3-(4-Fluoro-phenyl)-pyridin-2-yl)-N′-ethoxycarbonyl-thiourea

溶媒

dioxane

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the residue was used for the next step without purification

実験手順

To a solution of 3-(4-fluoro-phenyl)-pyridin-2-ylamine (200 mg, 1.06 mmol) in dioxane (10 mL) was added ethoxycarbonyl isothiocyanate (141 μL, 1.17 mmol) and stirred at room temperature for 12 hours. The solvent was evaporated and the residue was used for the next step without purification. The title compound was obtained as a light yellow solid (340 mg, 100%).

出典