反応 #538151

反応方程式

triphosgene

(S)-1-phenylpropan-1-amine

NaHCO3

→

(S)-(1-isocyanatopropyl)benzene

収率 88.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他The organic phase was separated
2. 2
   その他dried
3. 3
   濃縮concentrated

実験手順

To a solution of (S)-1-phenylpropan-1-amine (3.00 g, 14 mmol) in the mixture of methylene chloride (50 mL) and saturated NaHCO3 (50 mL) was added triphosgene (1.40 g, 4.60 mmol) at 0° C. The mixture was stirred for 15 minutes. The organic phase was separated, dried and concentrated to give (S)-(1-isocyanatopropyl)benzene (3.0 g, 88%). 1H NMR (CDCl3): δ=0.93 (q, 3H), 1.81 (m, 2H), 4.50 (m, 1H), 7.13 (m, 2H), 7.22 (m, 1H), 7.50 (m, 2H).

出典