反応 #5380

反応方程式

2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole

octyl iodide

potassium hydroxide

butanol

→

2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole

収率 56.6%

溶媒

water

反応条件

後処理

1. 1
   温度by refluxing for 310 minutes
2. 2
   抽出extracted from ethyl acetate
3. 3
   その他to obtain an organic layer
4. 4
   洗浄The organic layer was washed with water
5. 5
   乾燥dried with mirabilite
6. 6
   その他dried under reduced pressure
7. 7
   その他to obtain a resultant
8. 8
   その他The resultant was recrystallized from ethylacetate
9. 9
   その他to obtain a crystal
10. 10
    ろ過The crystal was filtered
11. 11
    その他purified by silica gel column chromatography (eluent: toluene)
12. 12
    その他recrystallized from acetone

実験手順

In a 30ml round-bottom flask, 0.47 g (1.48 m mole) of 2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole, 0.43 g (1.79 m mole) of octyl iodide, 0.12 g (1.82 m mole) of potassium hydroxide and 5 ml of butanol were placed, followed by refluxing for 310 minutes. The reaction mixture was poured into water, extracted from ethyl acetate to obtain an organic layer. The organic layer was washed with water dried with mirabilite and dried under reduced pressure to obtain a resultant. The resultant was recrystallized from ethylacetate to obtain a crystal. The crystal was filtered, purified by silica gel column chromatography (eluent: toluene) and recrystallized from acetone to obtain 0.36 g of 2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole (Yield: 56.6%). ##STR190##

出典