反応 #53786

反応方程式

HCl

1-Dodecanesulfonyl chloride

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

water

→

product

収率 44.9%

Dodecane-1-sulfonic acid [5-(5,6-difluoro-1H-indol-2-yl)-methoxy-phenyl]-amide

収率 44.9%

溶媒

pyridine

反応条件

後処理

1. 1
   ろ過After several hours the precipitate was filtered off
2. 2
   洗浄rinsed three times with water
3. 3
   その他dried
4. 4
   その他Recrystallization from ethanol

実験手順

1-Dodecanesulfonyl chloride (0.3 g, 1.1 mmol) was added to a stirred solution of 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine from Example 3 (0.3 g, 1.11 mmol) in pyridine (3 mL) under an inert atmosphere at room temperature. After approximately 20 hours the mixture was poured into water (30 mL), stirred, and acidified with aqueous HCl. After several hours the precipitate was filtered off, rinsed three times with water, and dried. Recrystallization from ethanol afforded the product (0.25 g), mp 148-149° C.

出典