反応 #53768

反応方程式

3,4-difluorophenylacetic acid

oxalyl chloride

→

3,4-Difluorophenylacetyl chloride

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   濃縮concentrated to an orange liquid that

実験手順

To a solution of 3,4-difluorophenylacetic acid (10.24 g, 60.4 mmol) in tetrahydrofuran (200 mL) and dimethylformamide (5 drops) at room temperature was added in 1 mL portions oxalyl chloride (11 mL, 126 mmol). The reaction mixture was stirred 2 hours at room temperature and concentrated to an orange liquid that was used directly in the next step.

出典