反応 #5375

反応方程式

2-nitro-4-acetylphenol

sodium hydroxide

sodium hydrosulfite

→

2-amino-4-acetylphenol

収率 39.1%

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise in 10 minutes
2. 2
   その他to precipitate a crystal
3. 3
   ろ過The crystal was filtered
4. 4
   その他recrystallized from a mixture solvent of methanol-water

実験手順

In a 300 ml three-neck flask, 5.00 g (27.6 m mole) of 2-nitro-4-acetylphenol and 75 ml of 2N-sodium hydroxide solution were placed. To the mixture solution, a solution, which 25.00 g of sodium hydrosulfite was dissolved in 75 ml to water, was added dropwise in 10 minutes. Then the mixture solution was stirred for 20 minutes at room temperature to precipitate a crystal. The crystal was filtered and recrystallized from a mixture solvent of methanol-water to obtain 1.63 g of 2-amino-4-acetylphenol (Yield: 39.1%).

出典