反応 #537017

反応方程式

((S)-7-cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid isopropyl ester

cesium carbonate

2-methoxybenzyl chloride

→

product

収率 98.3%

[(S)-7-Cyano-4-(2-methoxy-benzyl)-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl]-carbamic acid isopropyl ester

収率 98.3%

溶媒

DMF

water

反応条件

後処理

1. 1
   温度The reaction is cooled to room temperature
2. 2
   その他The white solid is collected
3. 3
   洗浄washed with water
4. 4
   その他The solid is dried in a 40° C. vacuum oven
5. 5
   その他After drying

実験手順

A mixture of ((S)-7-cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid isopropyl ester (2.0 g, 7.06 mmol) and cesium carbonate (3.22 g, 9.88 mmol) in DMF (40 mL) is treated with 2-methoxybenzyl chloride (1.16 g, 7.41 mmol). The reaction is heated at 50° C. for 18 h. The reaction is cooled to room temperature and diluted with water (300 mL). The white solid is collected and washed with water. The solid is dried in a 40° C. vacuum oven. After drying, 2.80 g (98%) product is obtained as a white solid. LC-ES/MS m/z 404 [M+H]+, TR=2.83 min.

出典