反応 #536973

ord-9374823017d143f1a784e1a60c0199c4

反応方程式

Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1
lamotrigine
O=C(O)CCCCC(=O)O
adipic acid
→
Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1.O=C([O-])CCCCC(=O)[O-]
Lamotrigine Adipate

反応物

Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1
lamotrigine
O=C(O)CCCCC(=O)O
adipic acid

試薬

なし

溶媒

CO
methanol

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他to form a single solution
  2. 2
    workup.WAITto stand for several hours
  3. 3
    その他the slow evaporation of solvent
  4. 4
    その他cap vials for subsequent analysis

実験手順

16 mg of lamotrigine was dissolved in 2 ml of methanol, 11 mg of adipic acid was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08486927B2uspto-grants-2013_07