反応 #53550

反応方程式

nitric acid

2-bromo-m-xylene

→

2,6-dimethyl-3-nitrobromobenzene

溶媒

acetic acid

反応条件

後処理

1. 1
   温度cooled in an ice bath (above freezing point)
2. 2
   温度heated at 80° C. for 2 hours or until the reaction
3. 3
   温度The reaction mixture is cooled to room temperature
4. 4
   workup.STIRRINGwith stirring
5. 5
   その他The resulting yellow precipitates
6. 6
   ろ過are collected by suction filtration and air
7. 7
   その他dried

実験手順

Fuming nitric acid (>90% yellow fuming HNO3) is slowly added to a solution of 2-bromo-m-xylene (20 g, 150 mmol) in acetic acid (100 ml) cooled in an ice bath (above freezing point). The resulting mixture is allowed to warm to room temperature, stirred for 1 hour, and heated at 80° C. for 2 hours or until the reaction is shown to be complete by GC/MS analysis following micro-scale base work-up. The reaction mixture is cooled to room temperature and poured into ice/water with stirring. The resulting yellow precipitates are collected by suction filtration and air dried to obtain 2,6-dimethyl-3-nitrobromobenzene.

出典