反応 #53514

反応方程式

glycidyl tosylate

2-amino-3-nitrophenol

K2CO3

→

title compound

2-amino-3-nitro-1-(2,3-epoxypropoxy)benzene

溶媒

acetone

反応条件

後処理

1. 1
   温度the mixture is heated
2. 2
   温度at reflux for 18 hours
3. 3
   ろ過The mixture is filtered
4. 4
   その他the solvent is evaporated under reduced pressure
5. 5
   その他The crude reaction product
6. 6
   その他is purified by flash chromatography, elution

実験手順

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

出典