反応 #53442

反応方程式

d-tartaric acid

N-[(3R)— 1-azabicyclo[2.2.2]oct-3-yl]-6-bromopyrrolo[1,2-a]pyrazine-3-carboxamide

triethylamine

propargyl alcohol

→

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(3-hydroxyprop-1-ynyl)pyrrolo [1,2-a]pyrazine-3-carboxamide Tartrate

収率 24.0%

溶媒

dioxane

反応条件

後処理

1. 1
   その他The reaction vessel is purged with argon
2. 2
   ろ過is filtered through a plug of celite,
3. 3
   濃縮concentrated to dryness
4. 4
   workup.DISSOLUTIONthe residue dissolved in CHCl3 (150 mL) that
5. 5
   洗浄is washed with a solution
6. 6
   workup.ADDITIONcontaining 1:1 NH4OH/brine (5×35 mL)
7. 7
   その他The residue is purified
8. 8
   その他to give a pale orange colored oil that
9. 9
   その他crystallized from EtOH/Et2O
10. 10
    その他to give a tan solid

実験手順

To an argon sparged solution of N-[(3R)— 1-azabicyclo[2.2.2]oct-3-yl]-6-bromopyrrolo[1,2-a]pyrazine-3-carboxamide (0.230 g, 0.92 mmol), triethylamine (3.2 mL, 23.0 mmol) in dioxane (5 mL) is added copper (I) iodine (0.054 g, 0.28 mmol), propargyl alcohol (0.22 mL, 3.68 mmol), and dichlorobis(triphenylphosphino)-palladium (II) (0.063 g, 0.09 mmol). The reaction vessel is purged with argon, and stirred at 80° C. for 20 h at which point it is filtered through a plug of celite, concentrated to dryness, and the residue dissolved in CHCl3 (150 mL) that is washed with a solution containing 1:1 NH4OH/brine (5×35 mL). The residue is purified using silica gel chromatography (5% MeOH/CH2Cl2 gradient up to 10% MeOH/CH2Cl2) to give a pale orange colored oil that is salted with d-tartaric acid, and crystallized from EtOH/Et2O to give a tan solid. Yield 24%. HRMS (FAB) calcd for C18H20N4O2+H 325.1664, found 325.1664.

出典