反応 #534400

反応方程式

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

→

desired compound

1-(4-Fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過The suspension was filtered through a dicalite speed plus pad
2. 2
   洗浄washed with 1 L methylene chloride
3. 3
   その他The solvents were evaporated

実験手順

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol (7.16 g, 34.7 mmol) was dissolved in 2.3 L methylene chloride. Mangan (IV) oxid (26.8 g, 278 mmol) was added and the reaction mixture was stirred at room temperature for 3 days. The suspension was filtered through a dicalite speed plus pad and washed with 1 L methylene chloride. The solvents were evaporated and the desired compound was obtained as a white solid (5.87 g, 83%), MS: m/e=205.1 (M+H+).

出典