反応 #53437
ord-8e64fb0de175486682f4ed35ca9f9ed1
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1乾燥The resulting suspension is dried (Na2SO4)
- 2ろ過filtered through celite
- 3濃縮After concentration under reduced pressure
- 4その他the white solid (34.0 g) is crystallized from EtOAc/hexanes
実験手順
To a suspension of lithium aluminum hydride (10.6 g, 264 mmol) in THF (200 mL) is added dropwise a solution of ethyl indole-2-carboxylate (50.0 g, 256 mmol) in THF (250 mL) over 25 minutes. After 3 h, water (10.6 mL) is carefully added, followed by 15% NaOH (10.6 mL), followed by additional portion of water (31.8 mL). The resulting suspension is dried (Na2SO4) and filtered through celite. After concentration under reduced pressure, the white solid (34.0 g) is crystallized from EtOAc/hexanes to give white needles for 1H-indol-2-ylmethanol. Yield 83%. HRMS (FAB) calcd for C9H9NO+H 148.0762, found 148.0771.