反応 #53429

反応方程式

compound

1-Allyloxy-2-chloromethylbenzene

ammonia

→

(2-Allyloxy-benzyl)amine

反応条件

後処理

1. 1
   その他The reaction mixture is evaporated in vacuo
2. 2
   その他the mixture is evaporated again
3. 3
   抽出extracted several times with water
4. 4
   その他The aqueous phase is evaporated to a very great extent
5. 5
   その他an oil being obtained which
6. 6
   その他crystallizes on standing

実験手順

3.0 g (16.4 mmol) of the compound from Example I are boiled under reflux for 17 hours in 250 ml of a saturated methanolic ammonia solution. The reaction mixture is evaporated in vacuo, the residue is taken up in methanol and the mixture is evaporated again; this process is repeated a few times. The crude product is taken up in dichloromethane and extracted several times with water. The aqueous phase is evaporated to a very great extent, an oil being obtained which crystallizes on standing.

出典