反応 #53421

反応方程式

4-[4-(2{t-butoxycarbonylamino}ethyloxy)phenyl]butylamine

butylamidino-3,5-diamino-6-chloropyrazinecarboxamide

→

4-[4-(2-aminoethyloxy)pheny)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

反応条件

実験手順

Using general procedure Z, 4-[4-(2{t-butoxycarbonylamino}ethyloxy)phenyl]butylamine was converted into 4-[4-(2-{t-butoxycarbonylamino}ethyloxy)phenyl)]butylamidino-3,5-diamino-6-chloropyrazinecarboxamide, m.p. 118° C., APCI MS M/Z=521[C23H33ClN8O4+H]+, which was hydrolyzed and acidified with HCL to give 4-[4-(2-aminoethyloxy)pheny)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, m.p. >178° C. (dec), M/Z=421 [C18H25ClN8O2].

出典