反応 #5337

反応方程式

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

溶媒

dioxane

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated to dryness
2. 2
   その他The residue was crystallized from ethyl acetate (50 ml)
3. 3
   その他Resulting crystalline precipitates
4. 4
   ろ過were collected by filtration

実験手順

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

出典