反応 #53350

反応方程式

starting material XVIII

(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

triethyl orthoformate

hydrochloric acid

→

title compound

収率 77.0%

(±)-8-Methyl-5-(4-nitrophenyl)-7-(1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

収率 77.0%

反応条件

後処理

1. 1
   温度After cooling the precipitated crystals
2. 2
   ろ過were filtered off
3. 3
   洗浄washed with ethanol
4. 4
   その他dried

実験手順

A mixture of 0.57 g (1.43 mmol) of the starting material XVIII, 6 ml of triethyl orthoformate and a catalytic amount of hydrochloric acid was stirred at 80° C. for 1 h. After cooling the precipitated crystals were filtered off, washed with ethanol and dried to yield 0.45 g (77%) of the title compound; Mp.: 212-213° C.

出典