反応 #53345

反応方程式

starting material I

(±)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

ethyl bromopyruvate

→

title compound

収率 85.0%

(±)-7-(4-Ethoxycarbonyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

収率 85.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度After cooling the precipitated crystals
2. 2
   ろ過were filtered off
3. 3
   洗浄washed with ethanol
4. 4
   その他dried

実験手順

A mixture of 0.45 g (1.17 mmol) of the starting material I, 0.46 g (2.36 mmol) of ethyl bromopyruvate and 7 ml of dimethylformamide was stirred at 80° C. for 30 min. After cooling the precipitated crystals were filtered off, washed with ethanol and dried to yield 0.41 g (85%) of the title compound; Mp.: 242-243° C.

出典