反応 #533374

反応方程式

Benzenethiol

sodium ethoxide

1-bromo-2-chloroethane

water

→

2-chloroethyl phenyl sulfide

収率 74.0%

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   抽出The mixture was extracted three times with ether
2. 2
   乾燥the combined organic layer was dried over magnesium sulfate
3. 3
   その他After removal of the solvent
4. 4
   その他the compound was purified by flash chromatography

実験手順

Benzenethiol (15.0 g, 0.136 mol) was added to the solution of sodium ethoxide (0.20 mol) in 200 ml of anhydrous ethanol, and the mixture was stirred at room temperature for 15 minutes and then added to the solution of 1-bromo-2-chloroethane in 100 ml of ethanol. The resultant mixture was stirred at room temperature for 3 hours and poured into 300 ml of water. The mixture was extracted three times with ether and the combined organic layer was dried over magnesium sulfate. After removal of the solvent, the compound was purified by flash chromatography using heptane/ethyl acetate (100 to 97/3) as eluent in a yield of 74%.

出典