反応 #53321

反応方程式

Iodomethane

4-cyanophenyl-thiourea

→

methyl N′-(4-cyanophenyl)-carbamimidothioate

収率 84.0%

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The precipitate was filtered off
2. 2
   その他dried
3. 3
   workup.DISSOLUTIONdissolved in DCM
4. 4
   洗浄The organic solution was washed with NH3 (aq.) (excess)
5. 5
   乾燥dried with potassium carbonate
6. 6
   ろ過filtered
7. 7
   その他the solvent was evaporated

実験手順

Iodomethane (1.76 ml) was added to 4-cyanophenyl-thiourea (5.0 g) in acetone (100 ml). The reaction mixture was stirred overnight at RT. The precipitate was filtered off, dried and dissolved in DCM. The organic solution was washed with NH3 (aq.) (excess), dried with potassium carbonate, filtered, and the solvent was evaporated, yielding 4.53 g (84%, white solid) of methyl N′-(4-cyanophenyl)-carbamimidothioate (intermediate 6).

出典