反応 #53263

反応方程式

3-hydroxyhexadecanoic acid

triethylamine

benzyl bromide

→

benzyl 3-hydroxyhexadecanoate

溶媒

DMF

反応条件

後処理

1. 1
   その他After the solvent was removed in vacuo, ethyl acetate and water
2. 2
   workup.ADDITIONwere added to the residue
3. 3
   洗浄The separated ethyl acetate layer was washed twice with water
4. 4
   乾燥dried over anhydrous sodium sulfate
5. 5
   濃縮After concentration
6. 6
   その他the residue was purified by a silica gel column chromatography (silica gel 15 g, chloroform: methanol=100:0-8)

実験手順

To a solution of 3-hydroxyhexadecanoic acid (1.90 g) and triethylamine (0.97 ml) in DMF (20 ml) was added benzyl bromide (0.83 ml) and the mixture was stirred at room temperature for 3 days. After the solvent was removed in vacuo, ethyl acetate and water were added to the residue. The separated ethyl acetate layer was washed twice with water and then dried over anhydrous sodium sulfate. After concentration, the residue was purified by a silica gel column chromatography (silica gel 15 g, chloroform: methanol=100:0-8) to afford 1.22 g of benzyl 3-hydroxyhexadecanoate.

出典