反応 #53260

反応方程式

3-hydroxymyristic acid

triethylamine

benzyl bromide

→

benzyl 3-hydroxymyristate

溶媒

DMF

反応条件

後処理

1. 1
   その他After the solvent was removed in vacuo, to the residue
2. 2
   workup.ADDITIONwere added ethyl acetate and water
3. 3
   洗浄The separated ethyl acetate layer was washed twice with water
4. 4
   乾燥dried over anhydrous sodium sulfate
5. 5
   その他After the ethyl acetate was removed in vacuo, purification

実験手順

To a solution of 3-hydroxymyristic acid (5.00 g) and triethylamine (2.85 g) in DMF (50 ml) was added benzyl bromide (2.43 ml) and the mixture was stirred at room temperature overnight. After the solvent was removed in vacuo, to the residue were added ethyl acetate and water. The separated ethyl acetate layer was washed twice with water and then dried over anhydrous sodium sulfate. After the ethyl acetate was removed in vacuo, purification was carried out by a silica gel column chromatography (silica gel 30 g, chloroform:methanol=100:0-10) to afford 3.69 g of benzyl 3-hydroxymyristate.

出典