反応 #53217

反応方程式

isopropylsulphonic acid chloride

4-tert.butoxycarbonylamino-aniline

→

isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

溶媒

pyridine

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The organic phases are washed with water
3. 3
   その他The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1)

実験手順

1.2 g (10 mmol) of isopropylsulphonic acid chloride are added dropwise to a solution of 1.0 g (4.8 mmol) of 4-tert.butoxycarbonylamino-aniline in 10 ml of pyridine. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is poured onto 150 ml of ice water and then extracted with ethyl acetate. The organic phases are washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1).

出典