反応 #531835

反応方程式

N-butyl-N-methylamine

dicyclohexylcarbodiimide

dicyclohexylcarbodiimide

→

guanidine

収率 99.7%

1-Butyl-2,3-dicyclohexyl-1-methylguanidine

収率 99.7%

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度at reflux for 3 hours
3. 3
   濃縮is concentrated at 60° C. under 1 mbar for 2 hours
4. 4
   その他to give 29.9 g of a colorless and virtually odorless liquid of medium viscosity

実験手順

A mixture of 17.78 g of N-butyl-N-methylamine (0.204 mol) and 21.05 g of dicyclohexylcarbodiimide (0.102 mol) is heated at reflux for 3 hours. GC analysis then shows a conversion of more than 99.5% of the dicyclohexylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 1 mbar for 2 hours, to give 29.9 g of a colorless and virtually odorless liquid of medium viscosity, corresponding to the expected guanidine (99.7% yield).

出典