反応 #531803

反応方程式

4c

N-(Tris(3-benzyloxy-4-oxo-4H-pyran-2-yl)carboxyaminopropyl)methyl benzamide

→

title compound 6

収率 114.7%

N-(Tris(-3-hydroxy-4-oxo-4H-pyran-2-yl)carboxyaminopropyl)methyl benzamide

収率 114.7%

溶媒

acetic acid

hydrochloric acid

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated in vacuo
2. 2
   その他the residue azeotroped several times with methanol (10 ml)

実験手順

A solution of 4c (0.20 g, 0.20 mmol) in glacial acetic acid (2 ml) and concentrated hydrochloric acid (2 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo, the residue azeotroped several times with methanol (10 ml) to afford the title compound 6 (130 mg, 90%) as a red-orange solid.

出典