反応 #531796

反応方程式

compound 25

N-(11-(p-tolyloxy)undecyl)-3-(tritylthio)propaneamide

trifluoroacetic acid

triethylsilane

→

N-(11-(p-tolyloxy)undecyl)-3-mercaptopropaneamide

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   その他to obtain a brown-colored solution
2. 2
   workup.DISTILLATIONthe supernatant solution was distilled away under reduced pressure
3. 3
   その他The solid obtained
4. 4
   洗浄was washed twice with 30 ml of aqueous saturated sodium hydrogen carbonate solution and twice with 30 ml of saturated brine
5. 5
   その他the desiccant agent was removed by filtration
6. 6
   workup.DISTILLATIONthe solvent of the filtrate was distilled away under reduced pressure
7. 7
   その他The reaction mixture was purified by chromatography, and 0.1 g of the compound f, which
8. 8
   その他was obtained

実験手順

The compound 25 (0.181 g) was dissolved in 1 ml of methylene chloride, and 0.5 ml of trifluoroacetic acid was added to that while being stirred, to obtain a brown-colored solution. After a white-colored precipitate was generated by adding 0.16 ml of triethylsilane, the supernatant solution was distilled away under reduced pressure. The solid obtained was dissolved by the new addition of 20 ml of methylene chloride, and was washed twice with 30 ml of aqueous saturated sodium hydrogen carbonate solution and twice with 30 ml of saturated brine. After the collected organic phase was dehydrated with magnesium sulfate, the desiccant agent was removed by filtration, and the solvent of the filtrate was distilled away under reduced pressure. The reaction mixture was purified by chromatography, and 0.1 g of the compound f, which was a white solid, was obtained.

出典