反応 #531790

反応方程式

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

収率 95.7%

3-(tritylthio) propanoic acid

収率 95.7%

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他were carried out at room temperature
2. 2
   ろ過was filtered
3. 3
   洗浄was rinsed with 40 ml of diethyl ether
4. 4
   その他The precipitate was then dried under reduced pressure

実験手順

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

出典