反応 #531591

ord-783a3b8375f74c19a65838b24427a38f

反応方程式

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O
2,3-dichloro-5,6-dicyano-1,4-benzoquinone
→
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
1,4,6-cholestatrien-3 one
収率 56.0%

反応物

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O
2,3-dichloro-5,6-dicyano-1,4-benzoquinone

試薬

なし

溶媒

C1COCCO1
dioxane

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

1,4,6-cholestatrien-3 one was prepared in 56% yield from cholesterol, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and dioxane by the procedure of A. B. Turner J. Chem. Soc. C, 2568 (1968).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04264512uspto-grants-1981_04