反応 #53144

ord-bae006d86aca45239829c88f3660ae1f

反応方程式

Cl.NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1
(Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride
CC(C)C=O
isobutyraldehyde
[BH3-]C#N.[Na+]
sodium cyanoborohydride
→
CC(C)CN(Cc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1)CC(C)C
(Z)-3-[1-(4-Diisobutylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

反応物

Cl.NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1
(Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride
CC(C)C=O
isobutyraldehyde
[BH3-]C#N.[Na+]
sodium cyanoborohydride

試薬

なし

溶媒

CO
methanol

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 159 from (Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride, isobutyraldehyde and sodium cyanoborohydride in methanol.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06855710B2uspto-grants-2005_02