反応 #5310

反応方程式

Dihydropyran

4-chlorobutanol

→

title compound

収率 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

収率 89.9%

反応条件

後処理

1. 1
   洗浄washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   温度The dried liquid was heated under reduced pressure

実験手順

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

出典