反応 #53098

ord-354dbdbed1c745f78f285095acce9cf3

反応方程式

$CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

1-chloroethyl chloroformate

→

$CN(C(=O)CN1CCNCC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1.Cl.Cl$

(Z)-3-{1-[4-(N-piperazinomethylcarbonyl-N-methyl-amino)phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone-dihydrochloride

反応物

$CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

1-chloroethyl chloroformate

試薬

なし

溶媒

dichloromethane

反応条件

詳細条件

See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 54 from (Z)-3-{1-[4-(N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone and 1-chloroethyl chloroformate in dichloromethane.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06855710B2uspto-grants-2005_02