反応 #530841

反応方程式

2,6-di-tert.-butylphenol

hydrochloric acid

sodium

1,6-hexanediol

sodium

→

6-(3,5-di-tert.-butyl-4-hydroxyphenyl)hexanol

収率 66.6%

反応条件

後処理

1. 1
   その他fitted with a water trap
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   温度to cool
4. 4
   workup.ADDITIONthe base was neutralized by the addition of 5 ml
5. 5
   その他Sodium chloride from neutralization of the base was removed by filtration
6. 6
   workup.DISTILLATIONthe filtrate was distilled under vacuum

実験手順

To 1.15 grams of metallic sodium (0.05 moles) was added to 59 grams of 1,6-hexanediol (0.5 moles) in a 250 ml flask fitted with a water trap and the mixture was stirred until the sodium dissolved. There was then added 20.6 grams of 2,6-di-tert.-butylphenol (0.1 mole) and the mixture was heated for 7.5 hours at 225° C. The mixture was allowed to cool and the base was neutralized by the addition of 5 ml. of concentrated hydrochloric acid. Sodium chloride from neutralization of the base was removed by filtration and the filtrate was distilled under vacuum. There was obtained 20.4 grams (66.6% yield) of 6-(3,5-di-tert.-butyl-4-hydroxyphenyl)hexanol.

出典