反応 #530710

反応方程式

hydrogen

1,5-di-(phenyl)-3-pentanone

1,3-diamino-2-hydroxypropane

hydrogen

→

1-amino-3-[1,5-di-(phenyl)-3-pentylamino]-2-propanol

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   温度The resulting mixture is then heated
2. 2
   温度at reflux for about two hours
3. 3
   温度to cool
4. 4
   ろ過The mixture is then filtered from the catalyst
5. 5
   濃縮concentrated in vacuo
6. 6
   その他to remove the ethanol
7. 7
   洗浄washed with water
8. 8
   乾燥dried over sodium sulfate
9. 9
   ろ過filtered
10. 10
    濃縮concentrated in vacuo

実験手順

A solution of 1,5-di-(phenyl)-3-pentanone (9.5 g., 0.04 mole) in 50 cc. of anhydrous ethanol is added dropwise over about 20 minutes to a stirred solution of 1,3-diamino-2-hydroxypropane (25 g., 0.27 mole) in 200 cc. of ethanol. The resulting mixture is then heated at reflux for about two hours, allowed to cool, 1.0 g. platinum oxide added, and the mixture reduced under a 40 psi hydrogen atmosphere until hydrogen uptake ceases. The mixture is then filtered from the catalyst, concentrated in vacuo to remove the ethanol, the residue taken up in ether (250 cc.), washed with water, dried over sodium sulfate, filtered and concentrated in vacuo to yield the product 1-amino-3-[1,5-di-(phenyl)-3-pentylamino]-2-propanol.

出典