反応 #530181

反応方程式

Meldrum's acid

p-toluene-sulphonic acid

bis-(6-hydroxyhexyl)malonate

piperidine acetate

1,6-hexanediol

→

3-(6-hydroxyhexoxycarbonyl)-7-diethylaminocoumarin

溶媒

water

acetone

反応条件

実験手順

In this scheme, bis-(6-hydroxyhexyl)malonate is first produced by reacting the Meldrum's acid and 1,6-hexanediol in the presence of a catalytic quantity of p-toluene-sulphonic acid with elimination of acetone and water. The bis-(6-hydroxyhexyl)malonate is then combined with 4-diethylaminosalicylic aldehyde in the presence of catalytic quantities of piperidine acetate to form the desired 3-(6-hydroxyhexoxycarbonyl)-7-diethylaminocoumarin.

出典