反応 #52900

反応方程式

4-(3-chlorophenyl)-2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid

3,3-diphenylpropylamine

WSC hydrochloride

→

title compound

2-amino-4-(3-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid (3,3-diphenylpropyl)amide

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度under cooling with ice, and they
2. 2
   濃縮After the concentration under reduced pressure
3. 3
   workup.ADDITIONthe reaction mixture was diluted with ethyl acetate
4. 4
   洗浄washed with saturated aqueous sodium chloride solution
5. 5
   乾燥The organic layer was dried over anhydrous magnesium sulfate
6. 6
   濃縮concentrated under reduced pressure
7. 7
   その他The residue was purified by the silica gel chromatography (hexane/ethyl acetate=2/1)

実験手順

158 mg (0.563 mmol) of 4-(3-chlorophenyl)-2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid and 178 mg (0.844 mmol) of 3,3-diphenylpropylamine were dissolved in 20 ml of dichloromethane. 162 mg (0.844 mmol) of WSC hydrochloride was added to the obtained solution under cooling with ice, and they were stirred at room temperature overnight. After the concentration under reduced pressure, the reaction mixture was diluted with ethyl acetate and then washed with saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=2/1) to obtain the title compound.

出典