反応 #52800

反応方程式

5-chlorosulfonyl-2-oxindole

isopropylamine

pyridine

→

5-isopropylaminosulfonyl-2-oxindole

収率 45.5%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The solid was collected by vacuum filtration
2. 2
   洗浄slurry-washed with hot ethanol
3. 3
   温度cooled
4. 4
   ろ過collected by vacuum filtration and vacuum
5. 5
   その他dried at 40° C.

実験手順

A suspension of 3 g of 5-chlorosulfonyl-2-oxindole, 1.15 g of isopropylamine and 1.2 mL of pyridine in 50 mL of dichloromethane was stirred at room temperature for 4 hours at which time a white solid was present. The solid was collected by vacuum filtration, slurry-washed with hot ethanol, cooled, collected by vacuum filtration and vacuum dried at 40° C. to give 1.5 g (45%) of 5-isopropylaminosulfonyl-2-oxindole.

出典