反応 #52764

反応方程式

5-aminosulfonyl-2-oxindole

indole-2-carbaldehyde

piperidine

→

3-(1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

収率 83.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The solid was collected by vacuum filtration
2. 2
   洗浄washed with cold ethanol
3. 3
   その他dried in a vacuum oven

実験手順

A mixture of 5-aminosulfonyl-2-oxindole (106 mg), indole-2-carbaldehyde (87 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (4 mg) in ethanol (2 mL) was held in a sealed tube at 90° C. for 3 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 140 mg (83% yield) of 3-(1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide as an orange solid.

出典