反応 #52756

反応方程式

5-aminosulfonyl-2-oxindole

3-methylindole-2-carbaldehyde

piperidine

→

3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

収率 71.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The solid was collected by vacuum filtration
2. 2
   洗浄washed with cold ethanol
3. 3
   その他dried in a vacuum oven

実験手順

A mixture of 5-aminosulfonyl-2-oxindole (84 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was held in a sealed tube at 90° C. overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 88 mg (71% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide.

出典