反応 #527192

反応方程式

Water

N,N-diisopropylethylamine

2,4-dichlorobenzylchloride

2-chloro-4-aminobenzoic acid

→

desired product

4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid

溶媒

methylene chloride

反応条件

後処理

1. 1
   乾燥the organic layer dried with Na2SO4
2. 2
   濃縮concentrated in vacuo

実験手順

To a stirred mixture of 5.19 g of 2-chloro-4-aminobenzoic acid in 150 ml of methylene chloride is added 7.86 g of N,N-diisopropylethylamine and 12.67 g of 2,4-dichlorobenzylchloride and stirring continued for 18 hours. Water is added to the filtrate and the organic layer dried with Na2SO4 and concentrated in vacuo to give 13.68 g of the desired product, m.p. 171°-175° C.

出典