反応 #526690

反応方程式

3-acetamido-6-fluoro-4-nitrobenzotrifluoride

→

3-amino-6-fluoro-4-nitrobenzotrifluoride

収率 66.0%

溶媒

HCl

EtOH

反応条件

後処理

1. 1
   温度was refluxed overnight
2. 2
   抽出it was extracted by ethyl acetate (2×5 mL)
3. 3
   乾燥The extract was dried over Mg2SO4
4. 4
   その他evaporated

実験手順

A mixture of 3-acetamido-6-fluoro-4-nitrobenzotrifluoride (593 mg, 2.23 mmol) in concentrated HCl (5 mL) and EtOH (5 mL) was refluxed overnight and it was extracted by ethyl acetate (2×5 mL). The extract was dried over Mg2SO4 and evaporated to give 328 mg (66%) of 3-amino-6-fluoro-4-nitrobenzotrifluoride. 1H NMR (CDCl3): δ6.105 (s, 2H); 7.110 (d, 1H, J=6.0 Hz); 7.979 (d, 1H, J=10.2 Hz).

出典