反応 #52658
ord-5e8a1e2bb0f9481c9e511871bbe592ce
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他the precipitate which formed
- 2ろ過was collected by vacuum filtration
- 3洗浄washed with 50 ml of water
- 4その他dried
実験手順
A solution of 5-chloroacetyl-2-oxindole (4.18 g) in trifluoroacetic acid (30 ml) was cooled in an ice bath and 4.65 g of triethylsilane added. The mixture was then stirred at room temperature for 3 hours. The mixture was poured into 150 ml of water and the precipitate which formed was collected by vacuum filtration, washed with 50 ml of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.