反応 #52617

反応方程式

LAH

3-[3-(4-methylpiperazin-1-yl)-3-oxo-propyl]-1,5,6,7-tetrahydroindol-4-one

water

→

3-[3-(4-methylpiperazin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole

収率 101.3%

溶媒

THF

反応条件

後処理

1. 1
   温度The mixture was then refluxed overnight
2. 2
   温度The mixture was then cooled
3. 3
   workup.ADDITIONwas added
4. 4
   ろ過filtered
5. 5
   その他to remove insolubles
6. 6
   濃縮The filtrate was concentrated

実験手順

LAH (2.6 g, 68 mmol) was added dropwise to a suspension of 3-[3-(4-methylpiperazin-1-yl)-3-oxo-propyl]-1,5,6,7-tetrahydroindol-4-one (5 g, 17 mmol) in THF (300 mL). The mixture was then refluxed overnight. The mixture was then cooled and 2.6 mL each of water followed by a few drops of 15% NaOH was added. The reaction was stirred at room temperature for 30 min and then filtered to remove insolubles. The filtrate was concentrated to give 4.5 g (100%) of 3-[3-(4-methylpiperazin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole.

出典