反応 #52615

反応方程式

5-aminolevulinic acid hydrochloride

1,3-cyclohexanedione

sodium acetate

→

3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid

収率 82.0%

溶媒

water

反応条件

後処理

1. 1
   温度cooled
2. 2
   その他The precipitate which formed
3. 3
   ろ過was collected by vacuum filtration
4. 4
   洗浄washed with 30% of ethanol in water
5. 5
   その他dried under vacuum

実験手順

A mixture of 5-aminolevulinic acid hydrochloride (1.68 g, 10 mmol), 1,3-cyclohexanedione (1.12 g, 10 mmol) and sodium acetate (1.64 g, 20 mmol) in water (10 mL) was stirred at 110° C. for 4 hr and then cooled. The precipitate which formed was collected by vacuum filtration, washed with 30% of ethanol in water and dried under vacuum to give 1.7 g (82%) of 3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid.

出典