反応 #52589

反応方程式

5-chlorosulfonyl-2-oxindole

methylamine

→

5-methylaminosulfonyl-2-oxindole

収率 88.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他formed
2. 2
   ろ過The precipitate was collected by vacuum filtration
3. 3
   洗浄washed twice with 5 mL of water
4. 4
   その他dried under vacuum at 40° C. overnight

実験手順

A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole in 10 mL 2M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours during which time a white solid formed. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

出典