反応 #5256

反応方程式

7-amino-cephalosporanic acid

boron trifluoride

isopropanol

→

3-isopropoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

溶媒

triethylamine

反応条件

後処理

1. 1
   その他were reacted
2. 2
   その他to obtain 16.25 g of raw product which
3. 3
   その他was purified by two successive treatments with hot hydrochloric acid and ammonium hydroxide

実験手順

Using the procedure of Step A of Example 8, 27.2 g of 7-amino-cephalosporanic acid, 170 ml of the etherate of boron trifluoride, 134 ml of isopropanol and 125 ml of triethylamine were reacted to obtain 16.25 g of raw product which was purified by two successive treatments with hot hydrochloric acid and ammonium hydroxide to obtain 5.8 g of 3-isopropoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid.

出典