反応 #52550

反応方程式

benzyl bromide

4-iodopyrazole

sodiumhydride

→

N-benzylpyrazole

溶媒

DMF

反応条件

後処理

1. 1
   その他Reaction mixture
2. 2
   濃縮was concentrated in vacuo
3. 3
   その他the residue was purified by column chromatography

実験手順

To a solution of 4-iodopyrazole (400 mg, 2 mmol) in DMF(4 mL) at 0° C. was added sodiumhydride (80 mg, 60% dispersion in mineral oil, 2 mmol) followed by benzyl bromide (342 mg, 2 mmol) and reaction micture was allowed to stir for 2 h. Reaction mixture was concentrated in vacuo and the residue was purified by column chromatography to give N-benzylpyrazole in almost quantitative yield. IH NMR 5.29 (s, 2H), 7.18-7.28 (m, 2H), 7.28-7.40 (m, 4H), 7.53 (s, 1H).

出典