反応 #52514

反応方程式

4-bromo-1-bromomethyl-2-methyl-benzene

Intermediate 138

4-bromo-1-bromomethyl-2-methyl-benzene

imidazole

NaH

→

title compound

1-(4-Bromo-2-methyl-benzyl)-1H-imidazole

溶媒

DMF

DMF

反応条件

後処理

1. 1
   温度The solution was cooled to room temperature
2. 2
   濃縮concentrated under reduced pressure

実験手順

A solution of imidazole (58.0 mg, 0.86 mmol) in 3 mL DMF was treated with NaH (20.0 mg, 0.86 mmol) and heated to 90° C. After 1 h a solution of 4-bromo-1-bromomethyl-2-methyl-benzene (Intermediate 138, 190.0 mg, 0.72 mmol) in 3 mL DMF was added and stirring at 90° C. continued for 1 hour. The solution was cooled to room temperature and concentrated under reduced pressure. The title compound, 160.0 mg (88%) was isolated by column chromatography (5% MeOH-EtOAc) as a colorless solid.

出典